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Ankylosing spondylitis is a form of chronic arthritis that involves inflammation of the spine and may cause some vertebra to fuse together, leading to stiffness, severe pain and discomfort. While ankylosing spondylitis cannot be cured, a variety of treatment options can help reduce the pain and ease the symptoms. Early signs of ankylosing spondylitis are typically pain and stiffness in the lower back and buttocks. Symptoms tend to develop gradually over several weeks or months, with dull and diffuse pain that may start on one side of the body and spread to the other, becoming worse in the morning and at night.

Ankylosing spondylitis (AS) is a chronic inflammatory disease causing axial arthritis, frequently resulting in inflammatory low back pain early in the disease course, with eventual severe impairment of spinal mobility due to structural changes ultimately leading to spinal fusion. 

Ankylosing spondylitis is a form of arthritis featuring chronic inflammation of the spine and the sacroiliac joints (sacroiliitis). It belongs to a group of arthritis conditions that tend to cause chronic inflammation of the spine (spondyloarthropathies). It affects males two to three times more commonly than females. It is a cause of back pain in adolescents and young adults. The tendency to develop ankylosing spondylitis is genetically inherited. The HLA-B27 gene can be detected in the blood of most patients with ankylosing spondylitis. It can also affect the eyes, heart, lungs, and occasionally the kidneys. The optimal treatment involves medications that reduce inflammation or suppress immunity, physical therapy, and exercise.

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