Iliotibial band syndrome is an overuse injury causing pain on the outside part of the knee especially during running when the heel strikes the ground. The iliotibial band runs along the lateral or outside aspect of the thigh, from the pelvis to the tibia, crossing both the hip and knee joints. The iliotibial band is an important stabilizer structure of the outermost part of the knee as the joint flexes and extends. The iliotibial band syndrome may be the result of a combination of issues, including poor training habits, poor flexibility of muscle, and other mechanical imbalances in the body, especially involving the low back, pelvis, hips, and knees. There can be a predisposition to develop IT band syndrome. Anatomy issues may include differences in the lengths of the legs (a leg-length discrepancy), an abnormal tilt to the pelvis, or bowed legs (genu varum). Rest, ice, compression, and elevation (RICE) and anti-inflammatory medications are first-line treatments.